TRAPPC14

trafficking protein particle complex subunit 14

Ensembl:
ENSG00000146826
UniProt:
Q8WVR3
OMIM:
618350
Synonyms:
C7ORF43, FLJ10925, MAP11

Cilia effects upon perturbation of TRAPPC14

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

TRAPPC14 interacts with the distal appendage proteins Fas-binding factor 1 (FBF1) and centrosomal protein 83 (CEP83), which shows here are required for GFP-Rabin8 centrosomal accumulation, supporting a role for the TRAPPII complex in tethering preciliary vesicles to the mother basal body during ciliogenesis (31467083).TRAPPC14 localized to basal body (25613900)

Model organism evidence

Danio rerio (1 reference)

The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.

PMIDs: 31467083