TRAPPC3

trafficking protein particle complex subunit 3

Ensembl:: ENSG00000054116
UniProt:: O43617
OMIM:: 610955
Synonyms:: BET3

Cilia effects upon perturbation of TRAPPC3

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Component of a mammalian TRAPPII complex. Required for Rabin8 centrosomal targeting prior to ciliogenesis. Knockdown impares cilia formation by inhibiting Rabin8 recruitment to the centrosome (21273506). Candidate gene for BBS (27894351).

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