TRAPPC8

trafficking protein particle complex subunit 8

Ensembl:: ENSG00000153339
UniProt:: Q9Y2L5
OMIM:: 614136
Synonyms:: GSG1, HST2706, KIAA1012, TRS85

Cilia effects upon perturbation of TRAPPC8

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia
Overexpression effect:: Unknown

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

TRAPPIII components, TRAPPC8 and TRAPPC12, are in the cilium formation, and TRAPPIII regulates ciliogenesis via its interaction with a ciliopathy protein, OFD1. TRAPPC8 and OFD1 inhibit that between OFD1 and TRAPPC12 (32258032)

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