TRIM15

tripartite motif containing 15

Ensembl:
ENSG00000204610
UniProt:
Q9C019
Synonyms:
RNF93, ZNF178, ZNFB7

Cilia effects upon perturbation of TRIM15

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=366, lfc=-2.54) PMID:30270045

Phenotypes

Mouse phenotype:
abnormal vocalization

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

TRIM proteins localize to the centrosome and regulate cilia formation through condensation, highlighting the potential of TRIM condensates as key modulators in centrosome and cilia biology(PMID: 40450692).