TRIM46

tripartite motif containing 46

Ensembl:
ENSG00000163462
UniProt:
Q7Z4K8
OMIM:
600986
Synonyms:
FLJ23229, TRIFIC

Cilia effects upon perturbation of TRIM46

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.05) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.83) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.87) PMID:41160700

Phenotypes

Mouse phenotype:
hyperactivity, increased thigmotaxis, decreased locomotor activity, decreased bone mineral content, increased leukocyte cell number

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration

Function

TRIM46 localized at cilia