TRIM6

tripartite motif containing 6

Ensembl:: ENSG00000121236
UniProt:: Q9C030
OMIM:: 607564
Synonyms:: RNF89

Cilia effects upon perturbation of TRIM6

Ciliogenesis screen results (5 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.67) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.64) PMID:41160700

Subcellular localization

cilia associated gene

Functional category

Ciliary assembly/disassembly
T cell biology
Viral interactions
Transcription regulation

Function

TRIM proteins localize to the centrosome and regulate cilia formation through condensation, highlighting the potential of TRIM condensates as key modulators in centrosome and cilia biology(PMID: 40450692).

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