TRIO

trio Rho guanine nucleotide exchange factor

Ensembl:
ENSG00000038382
UniProt:
O75962
OMIM:
601893
Synonyms:
ARHGEF23

Cilia effects upon perturbation of TRIO

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.19) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.0) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, abnormal embryo size, impaired glucose tolerance, increased neutrophil cell number
Human ciliopathy phenotype:
micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome; Intellectual disability

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • T cell biology
  • Neurogenesis & migration
  • Axon guidance & growth

Function

TRIO has localized in ciliary tip, primary cilia.