TRIP11

thyroid hormone receptor interactor 11

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000100815
UniProt:
Q15643
OMIM:
604505
Synonyms:
CEV14, GMAP-210, GMAP210, TRIP230

Cilia effects upon perturbation of TRIP11

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Kim2016: Not Reported
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, nucleus

References: PMID:41005307, PMID:19112494

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane
  • Cardiac & muscle development
  • ECM & connective tissue

Function

Anchores IFT20 to the Golgi complex. Interacts with IFT20 and to regulate sorting and/or trafficking of proteins from Golgi to the ciliary membrane. Required for efficient targeting of polycystin-2 to the cilium. Cilia in mutant cells are shorter (19112494)