TRIP11

thyroid hormone receptor interactor 11

Ensembl:
ENSG00000100815
UniProt:
Q15643
OMIM:
604505
Synonyms:
CEV14, GMAP-210, GMAP210, TRIP230

Cilia effects upon perturbation of TRIP11

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Kim2016: Not Reported
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane
  • Cardiac & muscle development
  • ECM & connective tissue

Function

Anchores IFT20 to the Golgi complex. Interacts with IFT20 and to regulate sorting and/or trafficking of proteins from Golgi to the ciliary membrane. Required for efficient targeting of polycystin-2 to the cilium. Cilia in mutant cells are shorter (19112494)

Model organism evidence

Mus musculus (1 reference)

Mass spectrometry and proteomic analysis determined endogenous binding between ciliary protein IFT20 and golgin protein GMAP210 in these osteoblasts.

PMIDs: 34128978

C. elegans (1 reference)

SQL-1, homologue of the Golgi protein GMAP210, modulates intraflagellar transport in C.

PMIDs: 23444385