TRIP13

Cilia effects upon perturbation of TRIP13

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

hyperactivity, decreased bone mineral content, increased total body fat amount, decreased grip strength, decreased hemoglobin content, increased circulating cholesterol level, decreased bone mineral density, increased blood urea nitrogen level, decreased erythrocyte cell number, abnormal tail morphology, abnormal bone structure, abnormal sleep behavior, abnormal digit morphology, increased fasting circulating glucose level, abnormal iris pigmentation, increased leukocyte cell number, prolonged rr interval, decreased hematocrit, increased vertical activity, increased circulating hdl cholesterol level, decreased lean body mass, abnormal coat/hair pigmentation, abnormal coat/ hair morphology, increased mean corpuscular hemoglobin, increased circulating alkaline phosphatase level, increased anxiety-related response

Mouse ciliopathy phenotype:

abnormal lens morphology, female infertility, male infertility, abnormal reti morphology

Subcellular localization

flagella, nucleus

Functional category

• Metabolism
• Reproduction & sperm
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)

Function

TRIP13 has localized in flagella.