TRPC1

transient receptor potential cation channel subfamily C member 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000144935
UniProt:: P48995
OMIM:: 602343
Synonyms:: HTRP-1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.09) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: decreased exploration in new environment, increased spleen weight, increased circulating alkaline phosphatase level

Subcellular localization

cilia

References: PMID:18323855

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Cardiac & muscle development
Muscle contraction & physiology

Function

TRPP2 and TRPC1 assemble to form a heteromeric channel with biophysical properties and modes of activation distinct from that of the individual channels. One of the physiological roles of this new channel is to mediate G-protein-coupled receptor (GPCR)-induced conductance in tive kidney epithelial cells(18323855).

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