TRPC1

transient receptor potential cation channel subfamily C member 1

Ensembl:
ENSG00000144935
UniProt:
P48995
OMIM:
602343
Synonyms:
HTRP-1

Cilia effects upon perturbation of TRPC1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.09) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased exploration in new environment, increased spleen weight, increased circulating alkaline phosphatase level

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

TRPP2 and TRPC1 assemble to form a heteromeric channel with biophysical properties and modes of activation distinct from that of the individual channels. One of the physiological roles of this new channel is to mediate G-protein-coupled receptor (GPCR)-induced conductance in tive kidney epithelial cells(18323855).

Model organism evidence

Mus musculus (1 reference)

Contributing to this knowledge gap is their resistance to drug screening campaigns, which are hindered by the unique subcellular trafficking of these channels to organelles such as the primary cilium.

PMIDs: 40518131