TRPM3

transient receptor potential cation channel subfamily M member 3

Ensembl:
ENSG00000083067
UniProt:
Q9HCF6
OMIM:
608961
Synonyms:
GON-2, KIAA1616, LTRPC3

Cilia effects upon perturbation of TRPM3

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
hyperactivity
Human ciliopathy phenotype:
neurodevelopmental disorder with hypotonia, dysmorphic facies, and skeletal anomalies, with or without seizures; cataract 50 with or without glaucoma

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

primary cilia are required for the maximal osmotic response in re l epithelial cells and that TRPM3 is involved in this mechanism and coexpression with acetylated 伪-tubulin and 纬-tubulin(28122715).

Model organism evidence

Mus musculus (2 references)

The TRPP2-dependent channel of renal primary cilia also requires TRPM3.

Primary cilia, which are mechanosensory organelles that sense changes in flow, are expressed on tubular epithelial cells.

PMIDs: 30883612, 30596515