TRPM4

transient receptor potential cation channel subfamily M member 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000130529
UniProt:
Q8TD43
OMIM:
606936
Synonyms:
FLJ20041

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.58) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:28122715, PMID:26290373

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • ECM & connective tissue

Function

TRPM4 is likely to influence the apical Ca²⁺