TRPM4
transient receptor potential cation channel subfamily M member 4
- Ensembl:
- ENSG00000130529
- UniProt:
- Q8TD43
- OMIM:
- 606936
- Synonyms:
- FLJ20041
Cilia effects upon perturbation of TRPM4
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.58) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Muscle contraction & physiology
- ECM & connective tissue
Function
TRPM4 is likely to influence the apical Ca虏鈦
Model organism evidence
Mus musculus (2 references)
Primary cilia of renal epithelial cells express several members of the transient receptor potential (TRP) class of cation-conducting channel, including TRPC1, TRPM3, TRPM4, TRPP2, and TRPV4.
A TRPM4-dependent current in murine renal primary cilia.