TSG101

tumor susceptibility 101

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000074319
UniProt:
Q99816
OMIM:
601387
Synonyms:
TSG10, VPS23

Cilia effects upon perturbation of TSG101

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.47) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased locomotor activity, preweaning lethality, complete penetrance

Subcellular localization

endosome, nucleus

References: PMID:37029318

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

TSG101 itself is not a ciliary protein, but it may functionally intersect with ciliary proteins like IFT20 outside the cilium — especially in T cells and immune signaling ( 37029318).