TSG101

Cilia effects upon perturbation of TSG101

Loss-of-function effect:

Longer cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.47) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased locomotor activity, preweaning lethality, complete penetrance

Mouse ciliopathy phenotype:

abnormal kidney morphology

Subcellular localization

cilia associated gene, endosome, nucleus

Functional category

• Ciliary assembly/disassembly
• T cell biology
• Viral interactions
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)

Function

TSG101 itself is not a ciliary protein, but it may functio lly intersect with ciliary proteins like IFT20 outside the cilium — especially in T cells and immune sig ling ( 37029318).

Model organism evidence