TSSK1B
testis specific serine kinase 1B
- Ensembl:
- ENSG00000212122
- UniProt:
- Q9BXA7
- OMIM:
- 610709
- Synonyms:
- FKSG81, SPOGA4, STK22D, TSSK1
Cilia effects upon perturbation of TSSK1B
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Ciliopathy associations
- Male Infertility
Subcellular localization
basal body, transition zone
Functional category
- Ciliary assembly/disassembly
- Reproduction & sperm
- Transition zone
Function
TSSK1B has localized in basal body, transition zone.
Model organism evidence
Drosophila (1 reference)
Phosphoproteomic analyses reveal that dTSSK2 coordinates sperm flagella assembly and motility by phosphorylating proteins involved in microtubule organization, organelle assembly, and flagella structure.
PMIDs: 40335644
Mus musculus (2 references)
Tssk4 is essential for maintaining the structural integrity of sperm flagellum.
In this study, the substrate of TSSK1 and 2, TSKS, was localized during spermiogenesis to the centrioles of post-meiotic spermatids, where it reached its greatest concentration during the period of flagellogenesis.