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Phenotypes

Mouse phenotype:

male infertility

Subcellular localization

Flagella associated gene

Function

We showed that TSSK2 and the late-CB associate with translation initiation factors and ribosomal proteins. Furthermore, we revealed an association of TSSK2 with a specific set of mRNAs that are enriched in polysome fractions in elongating spermatids, supporting the role of the late-CB in temporally regulated translation. These results link the function of the late-CB to RNA regulation during late spermatogenesis for the first time, providing important novel information about the RNA regulatory processes required for spermatogenesis and male fertility(41042594).