TSSK2

testis specific serine kinase 2

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000206203
OMIM:: 610710
Synonyms:: FLJ38613, SPOGA2, STK22B

Phenotypes

Mouse phenotype:: male infertility

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:41042594

Function

We showed that TSSK2 and the late-CB associate with translation initiation factors and ribosomal proteins. Furthermore, we revealed an association of TSSK2 with a specific set of mRNAs that are enriched in polysome fractions in elongating spermatids, supporting the role of the late-CB in temporally regulated translation. These results link the function of the late-CB to RNA regulation during late spermatogenesis for the first time, providing important novel information about the RNA regulatory processes required for spermatogenesis and male fertility(41042594).

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