TTC29

tetratricopeptide repeat domain 29

Ensembl:: ENSG00000137473
UniProt:: Q8NA56
OMIM:: 618735
Synonyms:: NYD-SP14

Cilia effects upon perturbation of TTC29

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.32) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse ciliopathy phenotype:: shortened qrs complex duration

Ciliopathy associations

Male Infertility

Subcellular localization

cilia, flagella

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm

Function

Also known as NYD-SP14. Strongly expressed in tissues with motile cilia and flagella. Functions in cilia and flagella, most likely as an inner-arm dynein subunit. Chlamydomo s homologue encodes 44kDa subunit of axonemal dynein (17981992). Involved in functio l interaction with the IFT machinery, participating in anterograde IFT. Mutations have been associated with multiple morphological abnormalities of the flagella (31735294).

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