TTC29

tetratricopeptide repeat domain 29

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000137473
UniProt:: Q8NA56
OMIM:: 618735
Synonyms:: NYD-SP14

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.32) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

Male Infertility

References: PMID:31735294

Subcellular localization

cilia, flagella

References: Human Protein Atlas, PMID:17981992, PMID:31735294

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm

Function

Also known as NYD-SP14. Strongly expressed in tissues with motile cilia and flagella. Functions in cilia and flagella, most likely as an inner-arm dynein subunit. Chlamydomonas homologue encodes 44kDa subunit of axonemal dynein (17981992). Involved in functional interaction with the IFT machinery, participating in anterograde IFT. Mutations have been associated with multiple morphological abnormalities of the flagella (31735294).

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