TTC39C

tetratricopeptide repeat domain 39C

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000168234
UniProt:: Q8N584
Synonyms:: C18ORF17, FLJ33761, HST2697

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.82) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=940, lfc=0.56) PMID:30270045

Phenotypes

Mouse phenotype:: increased hematocrit, increased erythrocyte cell number, decreased bone mineral density, irregularly shaped pupil

Subcellular localization

cilia

References: PMID:25860617, PMID:38989623

Functional category

Ciliary assembly/disassembly

Function

TTC39c has weak association with IFT144 and IFT139, two subunits of IFT-A(25860617). TTC39A/C and TMEM145 are localized to the cilia of sensory neurons in the head (amphid) and tail (phasmid) of C. elegans (38989623).

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