TTC4

tetratricopeptide repeat domain 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000243725
UniProt:
O95801
OMIM:
606753
Synonyms:
CNS1, FLJ41930, MGC5097

Cilia effects upon perturbation of TTC4

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-11.48) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=961, lfc=-1.81) PMID:30270045

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, limb grasping

Subcellular localization

cilia

References: PMID:25860617

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation

Function

TTC4 and TTC9c interacted specifically with BBS7 (25860617).