TTK

TTK protein kinase

Ensembl:
ENSG00000112742
UniProt:
P33981
OMIM:
604092
Synonyms:
CT96, MPH1, MPS1, MPS1L1

Cilia effects upon perturbation of TTK

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.96) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, embryonic lethality prior to organogenesis, decreased leukocyte cell number

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm

Function

Also known as MPS1. Negative regulator of ciliogenesis. Interacts with VDAC3 at the centrosome to promote ciliary disassembly during cell cycle entry and proliferation. Essential for the recruitment of Centrin 2 to the procentrioles (23388454).