TTK

TTK protein kinase

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000112742
UniProt:: P33981
OMIM:: 604092
Synonyms:: CT96, MPH1, MPS1, MPS1L1

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.96) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, embryonic lethality prior to organogenesis, decreased leukocyte cell number

Subcellular localization

cilia

References: PMID:23388454

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm

Function

Also known as MPS1. Negative regulator of ciliogenesis. Interacts with VDAC3 at the centrosome to promote ciliary disassembly during cell cycle entry and proliferation. Essential for the recruitment of Centrin 2 to the procentrioles (23388454).

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