TTLL10

tubulin tyrosine ligase like 10

Ensembl:
ENSG00000162571
UniProt:
Q6ZVT0
Synonyms:
FLJ36119, TTLL5

Cilia effects upon perturbation of TTLL10

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

TTLL10 produces R-polygly-recognized when co-expressed with TTLL8(28576883).

Model organism evidence

C. elegans (1 reference)

In humans, NEK10 mutation causes bronchiectasis, an airway and mucociliary transport disorder caused by defective motile cilia.

PMIDs: 33064774

Mus musculus (1 reference)

A photoreceptor specific ORF15 variant of RPGR (RPGR(ORF15)), carrying multiple Glu-Gly tandem repeats and a C-terminal basic domain of unknown function, localizes to the connecting cilium where it is thought to regulate cargo trafficking.

PMIDs: 27162334