TTLL13

tubulin tyrosine ligase like 13

Ensembl:
ENSG00000213471
UniProt:
A6NNM8
OMIM:
620485
Synonyms:
FLJ46079, MGC33417, TTLL13P

Cilia effects upon perturbation of TTLL13

Ciliogenesis screen results (1 screen)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.63) PMID:26167766

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

TTLL13 has localized in basal body.

Model organism evidence

Mus musculus (3 references)

Herein, we demonstrate an essential role for cilia and flagella associated protein 100 (CFAP100) in keratinocyte division.

By systematically screening enzymes of the TTLL family for specific functions in ependymal cilia, we demonstrate that the glycylating enzymes TTLL3 and TTLL8 were required for stability and maintenance of ependymal cilia, whereas the polyglutamylase TTLL6 was necessary for coordinated beating be

PMIDs: 40593606, 23897886, 22246503

Danio rerio (3 references)

We show that CEP41 is localized to the basal body and primary cilia, and regulates ciliary entry of TTLL6, an evolutionarily conserved polyglutamylase enzyme.

Similarly, knockdown of ttll6 strongly reduced cilia tubulin glutamylation but only partially affected cilia structure and motility.

PMIDs: 22246503, 21262966, 17761526

C. elegans (1 reference)

Cilia and basal bodies are essential organelles for a broad spectrum of functions, including the development of left-right asymmetry, kidney function, cerebrospinal fluid transport, generation of photoreceptor outer segments, and hedgehog signaling.

PMIDs: 17761526