TTLL4

tubulin tyrosine ligase like 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000135912
UniProt:
Q14679
OMIM:
618738
Synonyms:
KIAA0173

Cilia effects upon perturbation of TTLL4

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased bone mineral content, increased circulating ldl cholesterol level, increased circulating hdl cholesterol level

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

TTLL4 is present in cilia and in some cells also at the basal bodies (17499049).