TTLL7

tubulin tyrosine ligase like 7

Ensembl:
ENSG00000137941
UniProt:
Q6ZT98
OMIM:
618813
Synonyms:
FLJ23033

Cilia effects upon perturbation of TTLL7

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased grip strength

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

TTLL7 localize to both basal bodies and cilia(17499049).

Model organism evidence

Danio rerio (1 reference)

Similarly, knockdown of ttll6 strongly reduced cilia tubulin glutamylation but only partially affected cilia structure and motility.

PMIDs: 21262966