TTLL8

tubulin tyrosine ligase like 8

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000138892
UniProt:
A0A1C7CYW9
OMIM:
619193

Cilia effects upon perturbation of TTLL8

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

References: PMID:19427864, PMID:23897886, PMID:25180231

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

It may function in initiating glygylation modification by attaching the first glycine to tubulin. Interacts with TTLL10 and is required for TTLL10 efficient tubulin glycylation function (19427864). Redundant function with TTLL3, as both are unique monoglycylating enzymes in mammals. Required for stability and maintenance of motile ependymal cilia. Absence of TTL3 leads to absence of glycylation on axonemes, destabilising motile ependymal cilia and resulting in ciliary disassembly (23897886, 25180231).