TTLL9

tubulin tyrosine ligase like 9

Ensembl:: ENSG00000131044
UniProt:: Q3SXZ7
OMIM:: 619838
Synonyms:: C20ORF125, DJ310O13.1

Cilia effects upon perturbation of TTLL9

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
T cell biology
Reproduction & sperm
Cell migration & adhesion

Function

伪-tubulin glutamylase required for the elongation of the polyglutamate side chains, and for the normal assembly and function of cilia (18586949, 20188560).

Model organism evidence

Mus musculus (1 reference)

Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating.

PMIDs: 27257088

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