TTLL9

tubulin tyrosine ligase like 9

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000131044
UniProt:
Q3SXZ7
OMIM:
619838
Synonyms:
C20ORF125, DJ310O13.1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia

References: PMID:41005307, PMID:18586949, PMID:20188560

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

α-tubulin glutamylase required for the elongation of the polyglutamate side chains, and for the normal assembly and function of cilia (18586949, 20188560).