TUBA1A

tubulin alpha 1a

Ensembl:
ENSG00000167552
UniProt:
Q71U36
OMIM:
602529
Synonyms:
B-ALPHA-1, FLJ25113, TUBA3

Cilia effects upon perturbation of TUBA1A

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.10) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Phenotypes

Mouse phenotype:
hemorrhage, preweaning lethality, incomplete penetrance, edema, abnormal embryo size
Mouse ciliopathy phenotype:
abnormal facial morphology
Human ciliopathy phenotype:
Intellectual disability; congenital fibrosis of extraocular muscles

Subcellular localization

basal body, cilia, cytosol, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Viral interactions
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Alfa tubulin isoform. Component of the cytoskeleton, centrosomes and protofilaments, structures that associate laterally to form a microtubule.

Model organism evidence

Mus musculus (1 reference)

TUBA1A, TUBA1B, TUBA1C, TUBB2A, TUBB2B, TUBB4B, and TUBB5 were identified to be incorporated in ependymal cilia, with TUBB4B showing the highest expression.

PMIDs: 41459724

C. elegans (2 references)

The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.

Acetylation of the epsilon-amino group of K40 on alpha-tubulin is a conserved PTM on the luminal side of microtubules that was discovered in the flagella of Chlamydomonas reinhardtii.

PMIDs: 21068373, 20829795

Danio rerio (1 reference)

Acetylation of the epsilon-amino group of K40 on alpha-tubulin is a conserved PTM on the luminal side of microtubules that was discovered in the flagella of Chlamydomonas reinhardtii.

PMIDs: 20829795