TUBA1C

tubulin alpha 1c

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000167553
UniProt:
Q9BQE3
Synonyms:
BCM948, MGC10851, MGC14580, TUBA6

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-12.22) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased circulating alkaline phosphatase level

Subcellular localization

basal body, cilia, nucleus

References: PMID:41005307, PMID:24760594

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Alfa tubulin isoform. Component of the cytoskeleton, centrosomes and protofilaments, structures that associate laterally to form a microtubule.