TUBA3C

tubulin alpha 3c

Ensembl:
ENSG00000198033
UniProt:
P0DPH7
OMIM:
602528
Synonyms:
BA408E5.3, TUBA2

Cilia effects upon perturbation of TUBA3C

Ciliogenesis screen results (1 screen)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.20) PMID:26167766

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

TUBA3C has localized in primary cilia.

Model organism evidence

C. elegans (2 references)

The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.

Acetylation of the epsilon-amino group of K40 on alpha-tubulin is a conserved PTM on the luminal side of microtubules that was discovered in the flagella of Chlamydomonas reinhardtii.

PMIDs: 21068373, 20829795

Danio rerio (1 reference)

Acetylation of the epsilon-amino group of K40 on alpha-tubulin is a conserved PTM on the luminal side of microtubules that was discovered in the flagella of Chlamydomonas reinhardtii.

PMIDs: 20829795