TUBB2B

tubulin beta 2B class IIb

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000137285
UniProt:
Q9BVA1
OMIM:
612850
Synonyms:
BA506K6.1, DKFZP566F223, MGC8685

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.08) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance

Subcellular localization

basal body, cilia, flagella, nucleus, ciliary tip

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

Beta tubulin isoform. Component of the cytoskeleton, centrosomes and protofilaments, structures that associate laterally to form a microtubule.