TUBB4A
tubulin beta 4A class IVa
- Ensembl:
- ENSG00000104833
- UniProt:
- P04350
- OMIM:
- 602662
- Synonyms:
- BETA-5, DYT4, TUBB4
Cilia effects upon perturbation of TUBB4A
- Loss-of-function effect:
- No effect
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- decreased fasting circulating glucose level
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Viral interactions
- Protein processing & maturation
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Tubb4 protein, Tubb4a and Tubb4b, is localized to cilia in multiple lineages of multi-ciliated cells (MCCs) (38031972).
Model organism evidence
C. elegans (2 references)
One isotype, TBB-4, assembles into microtubules at the tips of the axoneme core and distal segments, where the microtubule tip tracker EB1 is found, and localizes all along the cilium, whereas the other, TBA-5, concentrates in distal singlets.
Primary cilia have essential roles in transducing signals in eukaryotes.