TUBB4A

tubulin beta 4A class IVa

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000104833
UniProt:
P04350
OMIM:
602662
Synonyms:
BETA-5, DYT4, TUBB4

Cilia effects upon perturbation of TUBB4A

Loss-of-function effect:
No effect

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased fasting circulating glucose level

Subcellular localization

cilia, ciliary tip, basal body

References: PMID:41005307, PMID:38031972

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Tubb4 protein, Tubb4a and Tubb4b, is localized to cilia in multiple lineages of multi-ciliated cells (MCCs) (38031972).