TUBB6

tubulin beta 6 class V

Ensembl:
ENSG00000176014
UniProt:
Q9BUF5
OMIM:
615103
Synonyms:
HST1601, MGC4083

Cilia effects upon perturbation of TUBB6

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=280, lfc=-2.18) PMID:30270045

Phenotypes

Human ciliopathy phenotype:
spinocerebellar ataxia type 28; spastic ataxia 5

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

TUBB6 has localized in basal body.

Model organism evidence

Xenopus (1 reference)

A Cell Type-Specific Role for Tubb6 in Ciliogenesis of Xenopus Epidermal Multiciliated Cells.

PMIDs: 40501596