TUBGCP2

Cilia effects upon perturbation of TUBGCP2

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.28) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.03) PMID:20393562

Phenotypes

Mouse phenotype:

abnormal bone structure, preweaning lethality, complete penetrance, embryonic lethality prior to organogenesis

Mouse ciliopathy phenotype:

abnormal sternum morphology

Human ciliopathy phenotype:

pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures

Subcellular localization

basal body, centrosome, cytosol

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Protein processing & maturation

Function

Also known as GCP2. Gamma tubulin complex protein. These type of complexes of gamma-tubulin are used as templates for the longitudi l association with 伪/尾-tubulin dimers during the nucleation process (29514869). Component of gamma- tubulin small complexes that then associate with associate with GCP4, GCP5 and GCP6 to form ring complexes (21725292).