TUBGCP5

tubulin gamma complex component 5

Ensembl:
ENSG00000276856, ENSG00000280807, ENSG00000275835
UniProt:
Q96RT8
OMIM:
608147
Synonyms:
GCP5, KIAA1899

Cilia effects upon perturbation of TUBGCP5

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.02) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.25) PMID:41160700

Subcellular localization

basal body, centrosome, cilia, cytosol, nucleus, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Transition zone

Function

Also known as GCP5. Required for the initial assembly of gamma-tubulin ring complexes and for their stabilization after assembly. These complexes are used as templates for the longitudi l association with 伪/尾-tubulin dimers during the nucleation process (29514869, 32317396). Associates with gamma-tubulin small complexes, GCP4 and GCP6 (21725292).