TUBGCP6

tubulin gamma complex component 6

Ensembl:: ENSG00000128159
UniProt:: Q96RT7
OMIM:: 610053
Synonyms:: DJ402G11.6, GCP6, KIAA1669

Cilia effects upon perturbation of TUBGCP6

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

Microcephaly

Subcellular localization

centrosome, cilia, cytosol, microtubules

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Protein processing & maturation

Function

Also known as GCP6. Required for the initial assembly of gamma-tubulin ring complexes and for their stabilization after assembly. These complexes are used as templates for the longitudi l association with 伪/尾-tubulin dimers during the nucleation process (29514869, 32317396). Associates with gamma-tubulin small complexes, GCP4 and GCP5 (21725292).

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