UBA3

ubiquitin like modifier activating enzyme 3

Ensembl:: ENSG00000144744
UniProt:: Q8TBC4
OMIM:: 603172
Synonyms:: HUBA3, NAE2, UBE1C

Cilia effects upon perturbation of UBA3

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.14) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Subcellular localization

centrosome, cilia, cytosol, nucleoplasm, plasma membrane

Function

The collection of regulators has diverse distributions throughout the cell with Bfar, Cop1, Cul9, Fancg, Skp1a, Uba3, Ube2l3, and Wwp1 showing weak localization to cilia. In addition, Sytl4 localized to the ciliary pocket at the base of the cilium, and Fbxw11 localized to centriolar satellites . Positive regulator of Hedgehog signaling(PMID: 34161574).

Model organism evidence

Mus musculus (1 reference)

Neddylation relieves cytoskeletal tension to permit primary cilia formation during mouse decidualization.

PMIDs: 41709324

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