UBE2B

ubiquitin conjugating enzyme E2 B

Ensembl:: ENSG00000119048
UniProt:: P63146
OMIM:: 179095
Synonyms:: HHR6B, RAD6B, UBC2

Cilia effects upon perturbation of UBE2B

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.43) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: increased leukocyte cell number, increased circulating alkaline phosphatase level, increased circulating phosphate level, decreased basophil cell number, preweaning lethality, incomplete penetrance, increased lymphocyte cell number, preweaning lethality, complete penetrance, decreased neutrophil cell number, decreased grip strength, abnormal coat appearance, limb grasping, abnormal gait, abnormal glucose homeostasis, abnormal behavior
Mouse ciliopathy phenotype:: enlarged heart

Subcellular localization

flagella, nucleus

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
T cell biology
Reproduction & sperm
Cell migration & adhesion

Function

UBE2B localized to flagella (25613900)

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