UBE2L3

ubiquitin conjugating enzyme E2 L3

Ensembl:
ENSG00000185651
UniProt:
P68036
OMIM:
603721
Synonyms:
UBCH7

Cilia effects upon perturbation of UBE2L3

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.46) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.9) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

Ube2l3 must be localized to cilia to function in regulating the ciliary levels of Smo (34161574).