UBR4

ubiquitin protein ligase E3 component n-recognin 4

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000127481
UniProt:: Q5T4S7
OMIM:: 609890
Synonyms:: KIAA0462, KIAA1307, P600, RBAF600, ZUBR1

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.32) PMID:29459680

Phenotypes

Mouse phenotype:: embryonic lethality prior to tooth bud stage, preweaning lethality, complete penetrance

Subcellular localization

basal body, centrosome, flagella, nucleus

References: PMID:25613900

Functional category

Ciliary assembly/disassembly

Function

UBR4 has localized in basal body,flagella.

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