UBR4

ubiquitin protein ligase E3 component n-recognin 4

Ensembl:: ENSG00000127481
UniProt:: Q5T4S7
OMIM:: 609890
Synonyms:: KIAA0462, KIAA1307, P600, RBAF600, ZUBR1

Cilia effects upon perturbation of UBR4

Ciliogenesis screen results (1 screen)

Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.32) PMID:29459680

Phenotypes

Mouse phenotype:: embryonic lethality prior to tooth bud stage, preweaning lethality, complete penetrance

Subcellular localization

basal body, centrosome, flagella, nucleus

Functional category

Ciliary assembly/disassembly

Function

UBR4 has localized in basal body,flagella.

Model organism evidence

Drosophila (1 reference)

Increased PCNT expression and its protein accumulation are linked to clinical conditions including cancer, mental disorders, and ciliopathies.

PMIDs: 37342879

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