UBR5

ubiquitin protein ligase E3 component n-recognin 5

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000104517
UniProt:: O95071
OMIM:: 608413
Synonyms:: DD5, EDD, EDD1, HYD, KIAA0896

Cilia effects upon perturbation of UBR5

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.52) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, casTLE effect=1.28) PMID:29459680

Subcellular localization

cilia, nucleus

References: PMID:29742019

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

Positive regulator of ciliogenesis. Ubiquitylates CSPP1 and is required for cytoplasmic organisation of CSPP1-associated centriolar satellites in centrosomal periphery. Regulates ciliogenesis via maintenance of centriolar satellite stability and CSPP1 localisation (29742019).

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