UBR5

ubiquitin protein ligase E3 component n-recognin 5

Ensembl:
ENSG00000104517
UniProt:
O95071
OMIM:
608413
Synonyms:
DD5, EDD, EDD1, HYD, KIAA0896

Cilia effects upon perturbation of UBR5

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.52) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, casTLE effect=1.28) PMID:29459680

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Positive regulator of ciliogenesis. Ubiquitylates CSPP1 and is required for cytoplasmic organisation of CSPP1-associated centriolar satellites in centrosomal periphery. Regulates ciliogenesis via mainte nce of centriolar satellite stability and CSPP1 localisation (29742019).

Model organism evidence

Mus musculus (1 reference)

An animal model for human immotile cilia syndrome.

PMIDs: 1992761