UBXN10

UBX domain protein 10

Ensembl:: ENSG00000162543
UniProt:: Q96LJ8
Synonyms:: FLJ25429, UBXD3

Cilia effects upon perturbation of UBXN10

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased circulating creatine kise level
Mouse ciliopathy phenotype:: increased circulating alanine transamise level

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly

Function

Facilitates recruitment of VCP to IFT-B. Interaction with VCP is required for UBXN10 ciliary localisation. Depletion of UBXN10 in zebrafish causes defects in left-right asymmetry (26389662).

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