UFL1

Subcellular localization

Endoplasmic reticulum

References: PMID:38666385

Function

Mechanistic studies show that the stability of KIF11 is regulated by an interplay between its UFMylation and ubiquitination, UFMylation of KIF11 at lysine 953 inhibits its ubiquitination by synoviolin 1 and thereby prevents its proteasomal degradation. The lysine 953-to-arginine mutant of KIF11 is more stable than wild-type KIF11 and also more effective in reversing the ciliary and retinal defects induced by KIF11 depletion. These findings identify a critical role for KIF11 UFMylation in the maintenance of photoreceptor cilium integrity and retinal homeostasis(38666385).