UGGT1

UDP-glucose glycoprotein glucosyltransferase 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000136731
UniProt:
Q9NYU2
OMIM:
605897
Synonyms:
HUGT1, UGCGL1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
abnormal blood vessel morphology, abnormal allantois morphology, abnormal pharyngeal arch morphology, embryonic growth retardation, edema, abnormal visceral yolk sac morphology, abnormal placenta morphology, preweaning lethality, complete penetrance, anophthalmia, abnormal neural tube morphology, abnormal vitelline vasculature morphology, abnormal craniofacial morphology

Subcellular localization

cilia, transition zone

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation

Function

UGGT1 localized at cilia