UGT2A1

UDP glucuronosyltransferase family 2 member A1 complex locus

Ensembl:
ENSG00000173610
UniProt:
P0DTE4
OMIM:
604716

Cilia effects upon perturbation of UGT2A1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.03) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased vertical activity

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

Treatment of the OE with beta-glucuronidase, an enzyme which counterbalance the UGTs activity, increased the response to eugenol which is a strong odorant UGT substrate(33765098).