ULK4

unc-51 like kinase 4

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000168038
UniProt:: Q96C45
OMIM:: 617010
Synonyms:: FAM7C1, FLJ20574, REC01035

Cilia effects upon perturbation of ULK4

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (3 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=183, lfc=0.69) PMID:30270045

Subcellular localization

basal body, cilia, transition zone

References: PMID:41005307, PMID:21746835, PMID:27445138

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

Hydrocephalus due to dysfunctional motile cilia in KO mouse, suggesting it may be involved in the development and/or function of motile cilia in the respiratory tract and ependyma (21746835). Essential for Ciliogenesis and CSF Flow. Modulates expression of the master regulator of ciliogenesis, Foxj1,its target genes and other ciliogenesis molecules, influencing axoneme structure, basal body alignment, cilia number and beating. Implicated in ciliopathy-related disorders (27445138).

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