UNC119

unc-119 lipid binding chaperone

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000109103
UniProt:: Q13432
OMIM:: 604011
Synonyms:: HRG4, POC7, POC7A, UNC119A

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

centrosome, cilia, cytosol, endosome

References: PMID:21642972, PMID:25501555

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

UNC119 bound Tα-GTP, inhibiting its GTPase activity, thereby providing a stable UNC119–Tα-GTP complex capable of diffusing from the inner segment back to the outer segment after light-induced translocation. UNC119 is a Gα subunit cofactor essential for G protein trafficking in sensory cilia(21642972). nphp-2 (the C. elegans Inversin homolog) and the doublet region genes arl-13, klp-11, and unc-119 are redundantly required for ciliogenesis(25501555).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.