UPF2

UPF2 regulator of nonsense mediated mRNA decay

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000151461
UniProt:
Q9HAU5
OMIM:
605529
Synonyms:
DKFZP434D222, KIAA1408, RENT2, SMG-3

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.16) PMID:41160700

Subcellular localization

cilia, cytosol, nucleus, ciliary tip

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

UPF2 has localized in cilia.