UPF3A

UPF3A regulator of nonsense mediated mRNA decay

Ensembl:
ENSG00000169062
UniProt:
Q9H1J1
OMIM:
605530
Synonyms:
HUPF3A, RENT3A, UPF3

Cilia effects upon perturbation of UPF3A

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.61) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal eye morphology, atrophy
Mouse ciliopathy phenotype:
small testis, abnormal testis morphology, male infertility

Subcellular localization

basal body, cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

UPF3A has localized in basal body, cilia.