USP14

ubiquitin specific peptidase 14

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000101557
UniProt:
P54578
OMIM:
607274
Synonyms:
TGT, UBP6

Cilia effects upon perturbation of USP14

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:30388222

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Deubiquitinating enzyme. Regulator of the ubiquitin proteasome system that controls controls ciliogenesis and cilium elongation, it positively affects Hh signalling through the degradation of Kif7. Controls Gli2 ciliary localisation ( 30388222).