USP21

ubiquitin specific peptidase 21

Ensembl:
ENSG00000143258
UniProt:
Q9UK80
OMIM:
604729
Synonyms:
USP16, USP23

Cilia effects upon perturbation of USP21

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.68) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

Loss of USP21 leads to the proteasomal degradation of DPYSL2 and causes a significant reduction in its centrosome abundance, ultimately resulting in ciliary defects (40619097). USP21 knockout mice exhibit ciliary defects in kidney, liver, and trachea. USP21 deubiquitinates DPYSL2 at the centrosome; loss leads to proteasomal degradation of DPYSL2 and ciliary defects.

Model organism evidence

Mus musculus (1 reference)

Ciliary defects are associated with diverse diseases collectively known as ciliopathies.

PMIDs: 40619097