USP33

ubiquitin specific peptidase 33

Ensembl:
ENSG00000077254
UniProt:
Q8TEY7
OMIM:
615146
Synonyms:
KIAA1097, VDU1

Cilia effects upon perturbation of USP33

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating cholesterol level, decreased body weight, increased circulating ldl cholesterol level, thrombocytosis, increased circulating hdl cholesterol level
Mouse ciliopathy phenotype:
increased circulating bilirubin level, increased circulating alanine transamise level, increased circulating aspartate transamise level

Subcellular localization

basal body, centrosome

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

USP33 interacts with CP110 and localizes to centrioles primarily in S and G2/M phases, the periods during which centrioles duplicate and elongate(23486064).